Literature

As a service to physicians, researchers, patients, and families, the registry has compiled a list of selected peer-reviewed references related to DIPG. This list is for information only. The registry does not endorse or recommend any of the specific conclusions or approaches to therapy described.

Abstracts and additional information available by selecting the links to PubMed.gov, a service of the US National Library of Medicine and the National Institutes of Health.

2021

Mesenchymal Stem Cells Successfully Deliver Oncolytic Virotherapy to Diffuse Intrinsic Pontine Glioma

Authors
Chastkofsky MI, Pituch KC, Katagi H, Zannikou M, Ilut L, Xiao T, Han Y, Sonabend AM, Curiel DT, Bonner ER, Nazarian J, Horbinski CM, James CD, Saratsis AM, Hashizume R, Lesniak MS, Balyasnikova IV.

Journal
Clin Cancer Res.

Complementary and alternative medicine in children with diffuse intrinsic pontine glioma-A SIOPE DIPG Network and Registry study

Authors
El-Khouly FE, Adil SM, Wiese M, Hulleman E, Hendrikse NH, Kaspers GJL, Kramm CM, Veldhuijzen van Zanten SEM, van Vuurden DG

Journal
Pediatric Blood and Cancer

Neogenin is highly expressed in diffuse intrinsic pontine glioma and influences tumor invasion (1)

Authors
Sesen J, Driscoll J, Shah N, Moses-Gardner A, Luiselli G, Alexandrescu S, Zurakowski D, Baxter PA, Su JM, Pricola Fehnel K, Smith ER

Journal
Brain Research

OLIG2 maintenance is not essential for diffuse intrinsic pontine glioma cell line growth but regulates tumor phenotypes (2)

Authors
Liao Y, Luo Z, Deng Y, Zhang F, Rao R, Wang J, Xu L, Kumar SS, Sengupta S, DeWire-Schottmiller M, Berry K, Garrett M, Fouladi M, Drissi R, Lu QR

Journal
Neuro-Oncology

Characteristics of Patients ≥ 10 Years of Age with Diffuse Intrinsic Pontine Glioma: A Report from the International DIPG Registry

Authors
Erker C, Lane A, Chaney B, Leary S, Minturn JE, Bartels U, Packer RJ, Dorris K, Gottardo NG, Warren KE, Broniscer A, Mark WK, Zhu X, White P, Dexheimer P, Black K, Asher A, DeWire-Shottmiller M, Hansford JR, Gururangan S, Nazarian J, Ziegler DS, Sandler E, Wagner L, Koschmann C, Fuller C, Drissi R, Jones BV, Leach J, Fouladi M.

Journal
Neuro-Oncology

Epigenomic landscape and 3D genome structure in pediatric high-grade glioma

Authors
Wang J, Huang TY, Hou Y, Bartom E, Lu X, Shilatifard A, Yue F, Saratsis A.

Journal
Science Advances

Epidemiology of brainstem high-grade gliomas in children and adolescents in the United States, 2000-2017

Authors
Patil N, Kelly ME, Yeboa DN, Buerki RA, Cioffi G, Balaji S, Ostrom QT, Kruchko C, Barnholtz-Sloan JS

Journal
Neuro-Oncology

Radiogenomics of diffuse intrinsic pontine gliomas (DIPGs): correlation of histological and biological characteristics with multimodal MRI features.

Authors
Calmon R, Dangouloff-Ros V, Varlet P, Deroulers C, Philippe C, Debily MA, Castel D, Beccaria K, Blauwblomme T, Grevent D, Levy R, Roux CJ, Purcell Y, Saitovitch A, Zilbovicius M, Dufour C, Puget S, Grill J, Boddaert N.

Journal
European Radiology

Design considerations of an IL13Rα2 antibody-drug conjugate for diffuse intrinsic pontine glioma

Authors
Lian X, Kats D, Rasmussen S, Martin LR, Karki A, Keller C, Berlow NE.

Journal
Acta Neuropathologica Communications

Evaluation of a patient-specific algorithm for predicting distribution for convection-enhanced drug delivery into the brainstem of patients with diffuse intrinsic pontine glioma

Authors
Wembacher-Schroeder E, Kerstein N, Bander ED, Pandit-Taskar N, Thomson R, Souweidane MM

Journal
J Neurosurg Pediatr

Retrospective study of diffuse intrinsic pontine glioma in the Belgian population: a 25 year experience

Authors
Ruttens D, Messiaen J, Ferster A, Piette C, Schifflers S, Van Damme A, van der Werff Ten Bosch J, Verlooy J, Willems L, Jacobs S

Journal
Journal of Neuro-Oncology

Diffuse intrinsic pontine glioma: a clinic in Mexico, social media, and unpublishable data

Authors
Bouche G, Bouffet E, Vandeborne L, Capistrano R, André N

Journal
Lancet Oncology

Tumor immune landscape of paediatric high-grade gliomas

Authors
Ross JL, Vega JV, Plant A, MacDonald TJ, Becher OJ, Hambardzumyan D

Journal
Brain

Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG

Authors
Ehteda A, Simon S, Franshaw L, Giorgi FM, Liu J, Joshi S, Rouaen JRC, Pang CNI, Pandher R, Mayoh C, Tang Y, Khan A, Ung C, Tolhurst O, Kankean A, Hayden E, Lehmann R, Shen S, Gopalakrishnan A, Trebilcock P, Gurova K, Gudkov AV, Norris MD, Haber M, Vittorio O, Tsoli M, Ziegler DS

Journal
Cell Reports

Endoscopic endonasal surgery to treat intrinsic brainstem lesions: correlation between anatomy and surgery

Authors
Topczewski TE, Somma AD, Culebras D, Reyes L, Torales J, Tercero A, Langdon C, Alobid I, Torne R, Roldan P, Prats-Galino A, Enseñat J.

Journal
Rhinology

Optimal therapeutic targeting by HDAC inhibition in biopsy-derived treatment-naïve diffuse midline glioma models

Authors
Vitanza NA, Biery MC, Myers C, Ferguson E, Zheng Y, Girard EJ, Przystal JM, Park G, Noll A, Pakiam F, Winter CA, Morris SM, Sarthy J, Cole BL, Leary SES, Crane C, Lieberman NAP, Mueller S, Nazarian J, Gottardo R, Brusniak MY, Mhyre AJ, Olson JM

Journal
Neuro-Oncology

Focused ultrasound mediated blood-brain barrier opening is safe and feasible in a murine pontine glioma model

Authors
Englander ZK, Wei HJ, Pouliopoulos AN, Bendau E, Upadhyayula P, Jan CI, Spinazzi EF, Yoh N, Tazhibi M, McQuillan NM, Wang TJC, Bruce JN, Canoll P, Feldstein NA, Zacharoulis S, Konofagou EE, Wu CC

Journal
Scientific Reports

NTRK Fusions Can Co-Occur With H3K27M Mutations and May Define Druggable Subclones Within Diffuse Midline Gliomas

Authors
Dahl NA, Donson AM, Sanford B, Wang D, Walker FM, Gilani A, Foreman NK, Tinkle CL, Baker SJ, Hoffman LM, Venkataraman S, Vibhakar R

Journal
Journal of Neuropathology and Experimental Neurology

Doxorubicin-Loaded Gold Nanoarchitectures as a Therapeutic Strategy against Diffuse Intrinsic Pontine Glioma

Authors
Ung C, Tsoli M, Liu J, Cassano D, Pocoví-Martínez S, Upton DH, Ehteda A, Mansfeld FM, Failes TW, Farfalla A, Katsinas C, Kavallaris M, Arndt GM, Vittorio O, Cirillo G, Voliani V, Ziegler DS

Journal
Cancers

MRI-based radiomics for prognosis of pediatric diffuse intrinsic pontine glioma: an international study

Authors
Tam LT, Yeom KW, Wright JN, Jaju A, Radmanesh A, Han M, Toescu S, Maleki M, Chen E, Campion A, Lai HA, Eghbal AA, Oztekin O, Mankad K, Hargrave D, Jacques TS, Goetti R, Lober RM, Cheshier SH, Napel S, Said M, Aquilina K, Ho CY, Monje M, Vitanza NA, Mattonen SA

Journal
Neuro-Oncology Advances

Ventricular size determination and management of ventriculomegaly and hydrocephalus in patients with diffuse intrinsic pontine glioma: an institutional experience

Authors
Fonseca A, Solano P, Ramaswamy V, Tabori U, Huang A, Drake JM, Tsang DS, Laperriere N, Bartels U, Kulkarni AV, Bouffet E

Journal
Journal of Neurosurgery

Variable expression of CXCR4 in molecular subtypes of infiltrating gliomas

Authors
Dono A, Zhu P, Zorofchian S, Takayasu T, Quezado MM, Rios A, Powers A, Esquenazi Y, Ballester LY.

Journal
Clinical Neuropathology

Receptor-driven invasion profiles in diffuse intrinsic pontine glioma

Authors
Karki A, Berlow NE, Kim JA, Hulleman E, Liu Q, Michalek JE, Keller C.

Journal
Neuro-Oncology Advances

Transcriptomic Analysis of Diffuse Intrinsic Pontine Glioma (DIPG) Identifies a Targetable ALDH-Positive Subset of Highly Tumorigenic Cancer Stem-like Cells

Authors
Surowiec RK, Ferris SF, Apfelbaum A, Espinoza C, Mehta RK, Monchamp K, Sirihorachai VR, Bedi K, Ljungman M, Galban S.

Journal
Molecular Cancer Research

Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas

Authors
Khan, A., Gamble, L.D., Upton, D.H. et al

Journal
Nature Communications

Clinical experience of convection-enhanced delivery (CED) of carboplatin and sodium valproate into the pons for the treatment of diffuse intrinsic pontine glioma (DIPG) in children and young adults after radiotherapy

Authors
Szychot E, Walker D, Collins P, Hyare H, Shankar A, Bienemann A, Hollingworth M, Gill S.

Journal
International Journal of Clinical Oncology

Clinical experience of convection-enhanced delivery (CED) of carboplatin and sodium valproate into the pons for the treatment of diffuse intrinsic pontine glioma (DIPG) in children and young adults after radiotherapy (1)

Authors
Szychot E, Walker D, Collins P, Hyare H, Shankar A, Bienemann A, Hollingworth M, Gill S

Journal
International Journal of Clinical Oncology

MRI-guided focused ultrasound enhances drug delivery in experimental diffuse intrinsic pontine glioma

Authors
Ishida J, Alli S, Bondoc A, Golbourn B, Sabha N, Mikloska K, Krumholtz S, Srikanthan D, Fujita N, Luck A, Maslink C, Smith C, Hynynen K, Rutka J.

Journal
Journal of Controlled Release

Neogenin is highly expressed in diffuse intrinsic pontine glioma and influences tumor invasion

Authors
Julie Sesen, Jessica Driscoll, Nishali Shah, Alexander Moses-Gardner, Gabrielle Luiselli, Sanda Alexandrescu, David Zurakowski, Patricia A. Baxter, Jack M. Su, Katie Pricola Fehnel, Edward R. Smith

Journal
Brain Research

Paediatric Gliomas: BRAF and Histone H3 as Biomarkers, Therapy and Perspective of Liquid Biopsies

Authors
Tan JY, Wijesinghe IVS, Alfarizal Kamarudin MN, Parhar I.

Journal
Cancers

T2-FLAIR Mismatch Sign and Response to Radiotherapy in Diffuse Intrinsic Pontine Glioma

Authors
Yamasaki F, Nishibuchi I, Karakawa S, Kaichi Y, Kolakshyapati M, Takano M, Yonezawa U, Imano N, Taguchi A, Shimomura M, Taniguchi M, Onishi S, Okada S, Awai K, Sugiyama K, Nagata Y.

Journal
Pediatric Neurosurgery

Advances in the classification and treatment of pediatric brain tumors (1)

Authors
Fangusaro J, Bandopadhayay P.

Journal
Current Opinion in Pediatrics

Craniospinal irradiation as a salvage treatment for metastatic relapsed DIPG

Authors
Perez-Somarriba M, Santa-Maria V, Cruz O, Muchart J, Lavarino C, Mico S, Morales La Madrid A.

Journal
Pediatric Blood and Cancer

Clinical approach to re-irradiation for recurrent diffuse intrinsic pontine glioma

Authors
Krishnatry R, Manjali JJ, Chinnaswamy G, Chatterjee A, Goda JS, Janu A, Sahu A, Jalali R, Gupta T.

Journal
Japanese Journal of Clinical Oncology

The Subventricular Zone, a Hideout for Adult and Pediatric High-Grade Glioma Stem Cells

Authors
Lombard A, Digregorio M, Delcamp C, Rogister B, Piette C, Coppieters N.

Journal
Frontiers in Oncology

The Prognostic Impact of Radiotherapy in Conjunction with Temozolomide in Diffuse Intrinsic Pontine Glioma: A Systematic Review and Meta-Analysis

Authors
Shi S, Lu S, Jing X, Liao J, Li Q.

Journal
World Neurosurgery

Harnessing brain development to understand brain tumours

Authors
Marino S, Gilbertson RJ.

Journal
Development

Therapeutic targeting of transcriptional elongation in diffuse intrinsic pontine glioma

Authors
Katagi H, Takata N, Aoi Y, Zhang Y, Rendleman EJ, Blyth GT, Eckerdt FD, Tomita Y, Sasaki T, Saratsis AM, Kondo A, Goldman S, Becher OJ, Smith E, Zou L, Shilatifard A, Hashizume R.

Journal
Neuro-Oncology

H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model

Authors
Haag D, Mack N, Benites Goncalves da Silva P, Statz B, Clark J, Tanabe K, Sharma T, Jäger N, Jones DTW, Kawauchi D, Wernig M, Pfister SM.

Journal
Cancer Cell

A pilot radiogenomic study of DIPG reveals distinct subgroups with unique clinical trajectories and therapeutic targets.

Authors
Zhu, X., Lazow, M.A., Schafer, A. et al.

Journal
Acta Neuropathologica Communications

Diffuse intrinsic pontine glioma: current insights and future directions

Authors
Srikanthan D, Taccone MS, Van Ommeren R, Ishida J, Krumholtz SL, Rutka JT

Journal
Chinese Neurosurgical Journal

Tumor genotype dictates radiosensitization after Atm deletion in primary brainstem glioma models

Authors
Deland K, Starr BF, Mercer JS, Byemerwa J, Crabtree DM, Williams NT, Luo L, Ma Y, Chen M, Becher OJ, Kirsch DG.

Journal
The Journal of Clinical Investigation

Brain stem gliomas and current landscape

Authors
Wummer B, Woodworth D, Flores C.

Journal
Journal of Neuro-Oncology

Pilot Study of Hyperpolarized 13 C Metabolic Imaging in Pediatric Patients with Diffuse Intrinsic Pontine Glioma and Other CNS Cancers

Authors
Autry AW, Park I, Kline C, Chen HY, Gordon JW, Raber S, Hoffman C, Kim Y, Okamoto K, Vigneron DB, Lupo JM, Prados M, Li Y, Xu D, Mueller S.

Journal
American Journal of Neuroradiology

2020

Epidemiology of brainstem high-grade gliomas in children and adolescents in the United States, 2000-2017 (1)

Authors
Patil N, Kelly ME, Yeboa DN, Buerki RA, Cioffi G, Balaji S, Ostrom QT, Kruchko C, Barnholtz-Sloan J.

Journal
Neuro-Oncology

Immune-stimulatory (TK/Flt3L) gene therapy opens the door to a promising new treatment strategy against brainstem gliomas

Authors
Faisal SM, Mendez FM, Nunez F, Castro MG, Lowenstein PR.

Journal
Oncotarget

High-grade gliomas in children and adolescents: is there a role for reoperation?

Authors
Silva da Costa MD, Camargo NC, Dastoli PA, Nicácio JM, Benevides Silva FA, Sucharski Figueiredo ML, Chen MJ, Cappellano AM, Saba da Silva N, Cavalheiro S.

Journal
Journal of Neurosurgery

Platelet-derived growth factor beta is a potent inflammatory drive in paediatric high-grade glioma

Authors
Ross JL, Chen Z, Herting CJ, Grabovska Y, Szulzewsky F, Puigdelloses M, Monterroza L, Switchenko J, Wadhwani NR, Cimino PJ, Mackay A, Jones C, Read RD, MacDonald TJ, Schniederjan M, Becher OJ, Hambardzumyan D.

Journal
Brain

A Protocol for the Generation of Treatment-naïve Biopsy-derived Diffuse Intrinsic Pontine Glioma and Diffuse Midline Glioma Models (1)

Authors
Biery MC, Noll A, Myers C, Morris SM, Winter CA, Pakiam F, Cole BL, Browd SR, Olson JM, Vitanza NA

Journal
Journal of Experimental Neurology

Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer

Authors
Pajovic S, Siddaway R, Bridge T, Sheth J, Rakopoulos P, Kim B, Ryall S, Agnihotri S, Phillips L, Yu M, Li C, Milos S, Patel P, Srikanthan D, Huang A, Hawkins C.

Journal
Nature Communications

Brain cancer induces systemic immunosuppression through release of non-steroid soluble mediators

Authors
Ayasoufi K, Pfaller CK, Evgin L, Khadka RH, Tritz ZP, Goddery EN, Fain CE, Yokanovich LT, Himes BT, Jin F, Zheng J, Schuelke MR, Hansen MJ, Tung W, Parney IF, Pease LR, Vile RG, Johnson AJ.

Journal
Brain

Impact of SCID mouse gender on tumorigenicity, xenograft growth and drug-response in a large panel of orthotopic PDX models of pediatric brain tumors

Authors
Qi L, Kogiso M, Du Y, Zhang H, Braun FK, Huang Y, Teo WY, Lindsay H, Zhao S, Baxter P, Zhao X, Yu L, Liu Z, Zhang X, Su JM, Adesina A, Yang J, Chintagumpala M, Perlaky L, Tsz-Kwong Man C, Lau CC, Li XN.

Journal
Cancer Lett.

Histone tail analysis reveals H3K36me2 and H4K16ac as epigenetic signatures of diffuse intrinsic pontine glioma

Authors
An S, Camarillo JM, Huang TY, Li D, Morris JA, Zoltek MA, Qi J, Behbahani M, Kambhampati M, Kelleher NL, Nazarian J, Thomas PM, Saratsis AM.

Journal
J Exp Clin Cancer Res.

Considerations when treating high-grade pediatric glioma patients with immunotherapy

Authors
Crotty E, Downey K, Ferrerosa L, Flores C, Hegde B, Raskin S, Hwang E, Vitanza N, Okada H.

Journal
Expert Rev Neurother.

OKlahoma Nitrone-007: novel treatment for diffuse intrinsic pontine glioma

Authors
Thomas L, Smith N, Saunders D, Zalles M, Gulej R, Lerner M, Fung KM, Carcaboso AM, Towner RA.

Journal
J Transl Med.

Histone Lysine-to-Methionine Mutation as Anticancer Drug Target

Authors
Yang J, Qiu Q, Chen L.

Journal
Advances in Experimental Medicine and Biology

Epigenetic-Targeted Treatments for H3K27M-Mutant Midline Gliomas

Authors
Lu VM, Daniels DJ.

Journal
Advances in Experimental Medicine and Biology

Histone H3K27M Mutation in Brain Tumors

Authors
El-Hashash A.H.K.

Journal
Advances in Experimental Medicine and Biology

Optimal therapeutic targeting by HDAC inhibition in biopsy-derived treatment-naïve diffuse midline glioma models (1)

Journal
Neuro Oncol.

Glucose transporter Glut1 controls diffuse invasion phenotype with perineuronal satellitosis in diffuse glioma microenvironment

Authors
Miyai M, Kanayama T, Hyodo F, Kinoshita T, Ishihara T, Okada H, Suzuki H, Takashima S, Wu Z, Hatano Y, Egashira Y, Enomoto Y, Nakayama N, Soeda A, Yano H, Hirata A, Niwa M, Sugie S, Mori T, Maekawa Y, Iwama T, Matsuo M, Hara A, Tomita H.

Journal
Neurooncol Adv.

Correlation of multimodal 18 F-DOPA PET and conventional MRI with treatment response and survival in children with diffuse intrinsic pontine gliomas

Authors
Morana G, Tortora D, Bottoni G, Puntoni M, Piatelli G, Garibotto F, Barra S, Giannelli F, Cistaro A, Severino M, Verrico A, Milanaccio C, Massimino M, Garrè ML, Rossi A, Piccardo A.

Journal
Theranostics.

Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG

Authors
Balakrishnan I, Danis E, Pierce A, Madhavan K, Wang D, Dahl N, Sanford B, Birks DK, Davidson N, Metselaar DS, Meel MH, Lemma R, Donson A, Vijmasi T, Katagi H, Sola I, Fosmire S, Alimova I, Steiner J, Gilani A, Hulleman E, Serkova NJ, Hashizume R, Hawkins C, Carcaboso AM, Gupta N, Monje M, Jabado N, Jones K, Foreman N, Green A, Vibhakar R, Venkataraman S.

Journal
Cell Reports

Hypofractionated radiotherapy versus conventional radiotherapy for diffuse intrinsic pontine glioma: A systematic review and meta-analysis

Authors
Park J, Yea JW, Park JW.

Journal
Medicine (Baltimore).

A comparative study of brain tumor cells from different age and anatomical locations using 3D biomimetic hydrogels

Authors
Wang C, Sinha S, Jiang X, Fitch S, Wilson C, Caretti V, Ponnuswami A, Monje M, Grant G, Yang F.

Journal
Acta Biomater.

A Novel Orthotopic Patient-Derived Xenograft Model of Radiation-Induced Glioma Following Medulloblastoma

Authors
Whitehouse JP, Howlett M, Hii H, Mayoh C, Wong M, Barahona P, Ajuyah P, White CL, Buntine MK, Dyke JM, Lee S, Valvi S, Stanley J, Andradas C, Carline B, Kuchibhotla M, Ekert PG, Cowley MJ, Gottardo NG, Endersby R.

Journal
Cancers (Basel).

A phase I trial of lenalidomide and radiotherapy in children with diffuse intrinsic pontine gliomas or high-grade gliomas

Authors
Hipp SJ, Goldman S, Kaushal A, Krauze A, Citrin D, Glod J, Walker K, Shih JH, Sethumadhavan H, O'Neill K, Garvin JH, Glade-Bender J, Karajannis MA, Atlas MP, Odabas A, Rodgers LT, Peer CJ, Savage J, Camphausen KA, Packer RJ, Figg WD, Warren KE.

Journal
J Neurooncol

A phase I/II study of ribociclib following radiation therapy in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG)

Authors
DeWire M, Fuller C, Hummel TR, Chow LML, Salloum R, de Blank P, Pater L, Lawson S, Zhu X, Dexheimer P, Carle AC, Kumar SS, Drissi R, Stevenson CB, Lane A, Breneman J, Witte D, Jones BV, Leach JL, Fouladi M

Journal
J Neurooncol

5-aminolevulinic acid-guided surgery for focal pediatric brainstem gliomas: A preliminary study

Authors
Labuschagne J.

Journal
Surg Neurol Int.

Targeting tumor hypoxia and mitochondrial metabolism with anti-parasitic drugs to improve radiation response in high-grade gliomas

Authors
Mudassar F, Shen H, O'Neill G, Hau E.

Journal
J Exp Clin Cancer Res.

Targeting metabolic/epigenetic pathways: a potential strategy for cancer therapy in diffuse intrinsic pontine gliomas

Authors
Zhao K, Miao H.

Journal
Signal Transduct Target Ther.

Pharmacologic inhibition of lysine-specific demethylase 1 as a therapeutic and immune-sensitization strategy in pediatric high-grade glioma

Authors
Bailey CP, Figueroa M, Gangadharan A, Yang Y, Romero MM, Kennis BA, Yadavilli S, Henry V, Collier T, Monje M, Lee DA, Wang L, Nazarian J, Gopalakrishnan V, Zaky W, Becher OJ, Chandra J.

Journal
Neuro Oncol.

Pediatric midline H3K27M-mutant tumor with disseminated leptomeningeal disease and glioneuronal features: case report and literature review

Authors
Navarro RE, Golub D, Hill T, McQuinn MW, William C, Zagzag D, Hidalgo ET.

Journal
Childs Nerv Syst.

Repeat convection-enhanced delivery for diffuse intrinsic pontine glioma

Authors
Bander ED, Ramos AD, Wembacher-Schroeder E, Ivasyk I, Thomson R, Morgenstern PF, Souweidane MM.

Journal
J Neurosurg Pediatr.

Cercosporamide inhibits bone morphogenetic protein receptor type I kinase activity in zebrafish

Authors
Hoeksma J, van der Zon GCM, Ten Dijke P, den Hertog J.

Journal
Dis Model Mech.

Integration of Multiple Platforms for the Analysis of Multifluorescent Marking Technology Applied to Pediatric GBM and DIPG

Authors
Pericoli G, Petrini S, Giorda E, Ferretti R, Ajmone-Cat MA, Court W, Conti LA, De Simone R, Bencivenga P, Palma A, Di Giannatale A, Jones C, Carai A, Mastronuzzi A, de Billy E, Locatelli F, Vinci M.

Journal
Int J Mol Sci.

Letter: High Prevalence of Developmental Venous Anomaly in Diffuse Intrinsic Pontine Gliomas: A Pediatric Control Study

Authors
Bray DP, Buster BE, Boucher AB, Wrubel DM.

Journal
Neurosurgery

In Reply: High Prevalence of Developmental Venous Anomaly in Diffuse Intrinsic Pontine Gliomas: A Pediatric Control Study

Authors
Roux A, Boddaert N, Varlet P, Pallud J.

Journal
Neurosurgery

Discovery, synthesis and characterization of a series of 7-aryl-imidazo[1,2-a]pyridine-3-ylquinolines as activin-like kinase (ALK) inhibitors

Authors
Engers DW, Bollinger SR, Felts AS, Vadukoot AK, Williams CH, Blobaum AL, Lindsley CW, Hong CC, Hopkins CR.

Journal
Bioorg Med Chem Lett.

Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas

Authors
Chung C, Sweha SR, Pratt D, Tamrazi B, Panwalkar P, Banda A, Bayliss J, Hawes D, Yang F, Lee HJ, Shan M, Cieslik M, Qin T, Werner CK, Wahl DR, Lyssiotis CA, Bian Z, Shotwell JB, Yadav VN, Koschmann C, Chinnaiyan AM, Blüml S, Judkins AR, Venneti S.

Journal
Cancer Cell

Development of a clinical scale for assessment of patients with diffuse intrinsic pontine glioma (DIPG) receiving experimental therapy: the PONScore

Authors
Hollingworth MA, Zacharoulis S.

Journal
J Neurooncol.

Epigenetic pathways and plasticity in brain tumors

Authors
Suter RK, Rodriguez-Blanco J, Ayad NG.

Journal
Neurobiol Dis.

Molecularly Targeted Treatments for NF1-Mutant Diffuse Intrinsic Pontine Glioma

Authors
Vitanza NA, Khalatbari H, Ermoian R, Sarthy J, Lockwood CM, Cole BL, Leary SES.

Journal
J Appl Lab Med.

Diffuse infiltrative pontine glioma biopsy in children with neuronavigation, frameless procedure: A single center experience of 10 cases

Authors
Joud A, Stella I, Klein O.

Journal
Neurochirurgie

Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma

Authors
Smil D, Wong JF, Williams EP, Adamson RJ, Howarth A, McLeod DA, Mamai A, Kim S, Wilson BJ, Kiyota T, Aman A, Owen J, Poda G, Horiuchi KY, Kuznetsova E, Ma H, Hamblin JN, Cramp S, Roberts OG, Edwards AM, Uehling D, Al-Awar R, Bullock AN, O'Meara JA, Isaac MB.

Journal
J Med Chem.

Combined treatment with CBP and BET inhibitors reverses inadvertent activation of detrimental super enhancer programs in DIPG cells

Authors
Wiese M, Hamdan FH, Kubiak K, Diederichs C, Gielen GH, Nussbaumer G, Carcaboso AM, Hulleman E, Johnsen SA, Kramm CM.

Journal
Cell Death Dis.

Mass cytometry detects H3.3K27M-specific vaccine responses in diffuse midline glioma

Authors
Mueller S, Taitt JM, Villanueva-Meyer JE, Bonner ER, Nejo T, Lulla RR, Goldman S, Banerjee A, Chi SN, Whipple NS, Crawford JR, Gauvain K, Nazemi KJ, Watchmaker PB, Almeida ND, Okada K, Salazar AM, Gilbert RD, Nazarian J, Molinaro AM, Butterfield LH, Prados MD, Okada H.

Journal
J Clin Invest.

Diffuse midline glioma: review of epigenetics

Authors
Cooney TM, Lubanszky E, Prasad R, Hawkins C, Mueller S.

Journal
J Neurooncol

High-grade gliomas in adolescents and young adults highlight histomolecular differences from their adult and pediatric counterparts

Authors
Roux A, Pallud J, Saffroy R, Edjlali-Goujon M, Debily MA, Boddaert N, Sanson M, Puget S, Knafo S, Adam C, Faillot T, Cazals-Hatem D, Mandonnet E, Polivka M, Dorfmüller G, Dauta A, Desplanques M, Gareton A, Pages M, Tauziede-Espariat A, Grill J, Bourdeaut F, Doz F, Dhermain F, Mokhtari K, Chretien F, Figarella-Branger D, Varlet P.

Journal
Neuro Oncol.

Diffuse Intrinsic Pontine Glioma Cells Are Vulnerable to Mitotic Abnormalities Associated with BMI-1 Modulation

Authors
Senthil Kumar S, Sengupta S, Zhu X, Mishra DK, Phoenix T, Dyer L, Fuller C, Stevenson CB, DeWire M, Fouladi M, Drissi R.

Journal
Mol Cancer Res.

Diffuse Intrinsic Pontine Glioma (DIPG): Breakthrough and Clinical Perspective

Authors
Perrone MG, Ruggiero A, Centonze A, Carrieri A, Ferorelli S, Scilimati A.

Journal
Curr Med Chem.

Teaching NeuroImages: Diffuse intrinsic pontine glioma in white matter

Authors
Lu VM, Brown DA, Quiñones-Hinojosa A, Chaichana KL, Daniels DJ.

Journal
Neurology

Causes of death in pediatric neuro-oncology: the sickkids experience from 2000 to 2017

Authors
Renzi S, Michaeli O, Ramaswamy V, Huang A, Stephens D, Maguire B, Tabori U, Bouffet E, Bartels U.

Journal
J Neurooncol

Correction to: Comparative multidimensional molecular analyses of pediatric diffuse intrinsic pontine glioma reveals distinct molecular subtypes

Authors
Saratsis AM, Kambhampati M, Snyder K, Yadavilli S, Devaney JM, Harmon B, Hall J, Raabe EH, An P, Weingart M, Rood BR, Magge SN, MacDonald TJ, Packer RJ, Nazarian J.

Journal
Acta Neuropathol.

A 2-year-old patient with a diffuse intrinsic pontine glioma and radiation-induced moyamoya syndrome

Authors
Iizuka A, Shiba N, Shimosato Y, Yoshitomi M, Nakamura T, Miyatake S, Takano Y, Sasaki K, Takeuchi M, Murata H, Yamamoto T, Matsumoto N, Ito S.

Journal
Pediatr Blood Cancer

Safety and efficacy of brainstem biopsy in children and young adults

Authors
Hersh DS, Kumar R, Moore KA, Smith LGF, Tinkle CL, Chiang J, Patay Z, Gajjar A, Choudhri AF, Lee-Diaz JA, Vaughn B, Klimo P.

Journal
J Neurosurg Pediatr.

PET, image-guided HDAC inhibition of pediatric diffuse midline glioma improves survival in murine models

Authors
Tosi U, Kommidi H, Adeuyan O, Guo H, Maachani UB, Chen N, Su T, Zhang G, Pisapia DJ, Dahmane N, Ting R, Souweidane MM.

Journal
Sci Adv.

Convection-Enhanced Delivery of Enhancer of Zeste Homolog-2 (EZH2) Inhibitor for the Treatment of Diffuse Intrinsic Pontine Glioma

Authors
Sasaki T, Katagi H, Goldman S, Becher OJ, Hashizume R.

Journal
Neurosurgery

Noncoding RNAs as potential biomarkers for DIPG diagnosis and prognosis: XIST and XIST-210 involvement

Authors
Velázquez-Flores MÁ, Rodríguez-Corona JM, López-Aguilar JE, Siordia-Reyes G, Ramírez-Reyes G, Sánchez-Rodríguez G, Ruiz Esparza-Garrido R.

Journal
Clin Transl Oncol.

Pontine gliomas a 10-year population-based study: a report from The Canadian Paediatric Brain Tumour Consortium (CPBTC)

Authors
Fonseca A, Afzal S, Bowes L, Crooks B, Larouche V, Jabado N, Perreault S, Johnston DL, Zelcer S, Fleming A, Scheinemann K, Silva M, Vanan MI, Mpofu C, Wilson B, Eisenstat DD, Lafay-Cousin L, Hukin J, Hawkins C, Bartels U, Bouffet E.

Journal
J Neurooncol.

Immune checkpoint inhibition for pediatric patients with recurrent/refractory CNS tumors: a single institution experience

Authors
Cacciotti C, Choi J, Alexandrescu S, Zimmerman MA, Cooney TM, Chordas C, Clymer J, Chi S, Yeo KK.

Journal
J Neurooncol.

Combined therapy of AXL and HDAC inhibition reverses mesenchymal transition in diffuse intrinsic pontine glioma

Authors
Meel MH, de Gooijer MC, Metselaar DS, Sewing ACP, Zwaan K, Waranecki P, Breur M, Buil LCM, Lagerweij T, Wedekind LE, Twisk JWR, Koster J, Hashizume R, Raabe EH, Montero Carcaboso Á, Bugiani M, Phoenix TN, van Tellingen O, van Vuurden DG, Kaspers GJL, Hulleman E.

Journal
Clinical Cancer Research

The integrated genomic and epigenomic landscape of brainstem glioma

Authors
Chen LH, Pan C, Diplas BH, Xu C, Hansen LJ, Wu Y, Chen X, Geng Y, Sun T, Sun Y, Zhang P, Wu Z, Zhang J, Li D, Zhang Y, Wu W, Wang Y, Li G, Yang J, Wang X, Xu C, Wang S, Waitkus MS, He Y, McLendon RE, Ashley DM, Yan H, Zhang L.

Journal
Nat Commun.

Children with DIPG and high-grade glioma treated with temozolomide, irinotecan, and bevacizumab: the Seattle Children's Hospital experience

Authors
Crotty EE, Leary SES, Geyer JR, Olson JM, Millard NE, Sato AA, Ermoian RP, Cole BL, Lockwood CM, Paulson VA, Browd SR, Ellenbogen RG, Hauptman JS, Lee A, Ojemann JG, Vitanza NA.

Journal
J Neurooncol.

Improving long-term survival in diffuse intrinsic pontine glioma

Authors
Felker J, Broniscer A.

Journal
Expert Rev Neurother.

A phase I/II study of veliparib (ABT-888) with radiation and temozolomide in newly diagnosed diffuse pontine glioma: a Pediatric Brain Tumor Consortium study

Authors
Baxter PA, Su JM, Onar-Thomas A, Billups CA, Li XN, Poussaint TY, Smith ER, Thompson P, Adesina A, Ansell P, Giranda V, Paulino A, Kilburn L, Quaddoumi I, Broniscer A, Blaney SM, Dunkel IJ, Fouladi M.

Journal
Neuro Oncol.

MR Imaging features of Diffuse Intrinsic Pontine Glioma (DIPG) and Relationship to Overall Survival: Report from the International DIPG Registry

Authors
Leach JL, Roebker J, Schafer A, et al.

Journal
Neuro-Oncology, 2020 Jun 6, Online Ahead of Print

MR imaging features of diffuse intrinsic pontine glioma and relationship to overall survival: report from the International DIPG Registry

Authors
Leach JL, Roebker J, Schafer A, Baugh J, Chaney B, Fuller C, Fouladi M, Lane A, Doughman R, Drissi R, DeWire-Schottmiller M, Ziegler DS, Minturn JE, Hansford JR, Wang SS, Monje-Deisseroth M, Fisher PG, Gottardo NG, Dholaria H, Packer R, Warren K, Leary SES, Goldman S, Bartels U, Hawkins C, Jones BV.

Journal
Neuro Oncol.

Bone morphogenetic protein receptors: Structure, function and targeting by selective small molecule kinase inhibitors

Authors
Sanchez-Duffhues G, Williams E, Goumans MJ, Heldin CH, Ten Dijke P.

Journal
Bone

Modeling human pediatric and adult gliomas in immunocompetent mice through costimulatory blockade

Authors
Lan X, Kedziorek DA, Chu C, Jablonska A, Li S, Kai M, Liang Y, Janowski M, Walczak P.

Journal
Oncoimmunology

STAT3 is a key molecule in the oncogenic behavior of diffuse intrinsic pontine glioma

Authors
Park J, Lee W, Yun S, Kim SP, Kim KH, Kim JI, Kim SK, Wang KC, Lee JY.

Journal
Oncol Lett.

Design of primers for direct sequencing of nine coding exons in the human ACVR1 gene

Authors
Matsuoka M, Tsukamoto S, Orihara Y, Kawamura R, Kuratani M, Haga N, Ikebuchi K, Katagiri T.

Journal
Bone

Development of a human in vitro blood-brain tumor barrier model of diffuse intrinsic pontine glioma to better understand the chemoresistance

Authors
Deligne C, Hachani J, Duban-Deweer S, Meignan S, Leblond P, Carcaboso AM, Sano Y, Shimizu F, Kanda T, Gosselet F, Dehouck MP, Mysiorek C.

Journal
Fluids Barriers CNS

Response assessment in diffuse intrinsic pontine glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group

Authors
Cooney TM, Cohen KJ, Guimaraes CV, Dhall G, Leach J, Massimino M, Erbetta A, Chiapparini L, Malbari F, Kramer K, Pollack IF, Baxter P, Laughlin S, Patay Z, Young Poussaint T, Warren KE.

Journal
Lancet Oncol.

Rare Diffuse Intrinsic Pontine Glioma Metastasis Throughout the Brain and Spine

Authors
Lu VM, Brown DA, Daniels DJ.

Journal
World Neurosurg.

Ad-CD40L mobilizes CD4 T cells for the treatment of brainstem tumors

Authors
Wongthida P, Schuelke MR, Driscoll CB, Kottke T, Thompson JM, Tonne J, Stone C, Huff AL, Wetmore C, Davies JA, Parker AL, Evgin L, Vile RG.

Journal
Neuro-Oncology

Targeting Sphingosine Kinase by ABC294640 against Diffuse Intrinsic Pontine Glioma (DIPG)

Authors
Dai L, Chen J, Lin Z, Wang Z, Mu S, Qin Z.

Journal
J Cancer.

Addition of Multimodal Immunotherapy to Combination Treatment Strategies for Children with DIPG: A Single Institution Experience

Authors
Van Gool SW, Makalowski J, Bonner ER, Feyen O, Domogalla MP, Prix L, Schirrmacher V, Nazarian J, Stuecker W.

Journal
Medicines (Basel).

Pontine Neoplasm or Myelinolysis Despite Normal Sodium Levels

Authors
Andereggen L, Remonda L.

Journal
World Neurosurg.

Decreased natural killer cells in diffuse intrinsic pontine glioma patients

Authors
Zhang L, Yu H, Xue Y, Liu Y.

Journal
Childs Nerv Syst.

Overcoming the Blood-Brain Barrier to Target Diffuse Intrinsic Pontine Glioma: What's New?

Authors
Lu VM, Power EA, Zhang L, Daniels DJ.

Journal
World Neurosurg.

MR Imaging Correlates for Molecular and Mutational Analyses in Children with Diffuse Intrinsic Pontine Glioma

Authors
Jaimes C, Vajapeyam S, Brown D, Kao PC, Ma C, Greenspan L, Gupta N, Goumnerova L, Bandopahayay P, Dubois F, Greenwald NF, Zack T, Shapira O, Beroukhim R, Ligon KL, Chi S, Kieran MW, Wright KD, Poussaint TY.

Journal
AJNR Am J Neuroradiol.

Oxaliplatin and [Pt(R,R-DACH)(panobinostat -2H)] show nanomolar cytotoxicity towards diffuse intrinsic pontine glioma (DIPG)

Authors
Boulet MHC , Marsh LK , Howarth A , Woolman A , Farrer NJ .

Journal
Dalton Trans.

Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma

Authors
Ensan D, Smil D, Zepeda-Velázquez CA, Panagopoulos D, Wong JF, Williams EP, Adamson R, Bullock AN, Kiyota T, Aman A, Roberts OG, Edwards AM, O'Meara JA, Isaac MB, Al-Awar R.

Journal
J Med Chem.

ABC Transporter Inhibition Plus Dexamethasone Enhances the Efficacy of Convection Enhanced Delivery in H3.3K27M Mutant Diffuse Intrinsic Pontine Glioma

Authors
Tsvankin V, Hashizume R, Katagi H, Herndon JE, Lascola C, Venkatraman TN, Picard D, Burrus B, Becher OJ, Thompson EM.

Journal
Neurosurgery

Tumor Response Assessment in Diffuse Intrinsic Pontine Glioma: Comparison of Semiautomated Volumetric, Semiautomated Linear, and Manual Linear Tumor Measurement Strategies

Authors
Gilligan LA, DeWire-Schottmiller MD, Fouladi M, DeBlank P, Leach JL.

Journal
AJNR Am J Neuroradiol.

Characterization of the Blood-Brain Barrier Integrity and the Brain Transport of SN-38 in an Orthotopic Xenograft Rat Model of Diffuse Intrinsic Pontine Glioma

Authors
Chaves C, Declèves X, Taghi M, Menet MC, Lacombe J, Varlet P, Olaciregui NG, Carcaboso AM, Cisternino S.

Journal
Pharmaceutics

Therapeutic Efficacy of Immune Stimulatory Thymidine Kinase and fms-like Tyrosine Kinase 3 Ligand (TK/Flt3L) Gene Therapy in a Mouse Model of High-Grade Brainstem Glioma

Authors
Mendez F, Kadiyala P, Nunez FJ, Carney S, Nunez FM, Gauss JC, Ravindran R, Pawar S, Edwards M, Garcia-Fabiani MB, Haase S, Lowenstein PR, Castro MG.

Journal
Clin Cancer Res.

Clinical, imaging, and molecular analysis of pediatric pontine tumors lacking characteristic imaging features of DIPG

Authors
Chiang J, Diaz AK, Makepeace L, Li X, Han Y, Li Y, Klimo P Jr, Boop FA, Baker SJ, Gajjar A, Merchant TE, Ellison DW, Broniscer A, Patay Z, Tinkle CL.

Journal
Acta Neuropathol Commun.

A Combined Approach of Convection-Enhanced Delivery of Peptide Nanofiber Reservoir to Prolong Delivery of DM1 for Diffuse Intrinsic Pontine Glioma Treatment

Authors
Bellat V, Alcaina Y, Tung CH, Ting R, Michel A, Souweidane M, Law B.

Journal
Neuro-Oncology

A combined approach of convection-enhanced delivery of peptide nanofiber reservoir to prolong local DM1 retention for diffuse intrinsic pontine glioma treatment

Authors
Bellat V, Alcaina Y, Tung CH, Ting R, Michel AO, Souweidane M, Law B.

Journal
Neuro-Oncology

A phase 2 study of valproic acid and radiation, followed by maintenance valproic acid and bevacizumab in children with newly diagnosed diffuse intrinsic pontine glioma or high-grade glioma

Authors
Su JM, Murray JC, McNall-Knapp RY, Bowers DC, Shah S, Adesina AM, Paulino AC, Jo E, Mo Q, Baxter PA, Blaney SM

Journal
Pediatric Blood and Cancer

A phase 2 study of valproic acid and radiation, followed by maintenance valproic acid and bevacizumab in children with newly diagnosed diffuse intrinsic pontine glioma or high-grade glioma (1)

Authors
Su JM, Murray JC, McNall-Knapp RY, Bowers DC, Shah S, Adesina AM, Paulino AC, Jo E, Mo Q, Baxter PA, Blaney SM.

Journal
Pediatr Blood Cancer.

Identification of new therapeutic targets and natural compounds against diffuse intrinsic pontine glioma (DIPG)

Authors
Chen J, Lin Z, Barrett L, Dai L, Qin Z.

Journal
Bioorg Chem.

Pontine Embryonal Tumor With Multilayered Rosettes: An Autopsy Case Exhibiting Extensive Posttreatment Glial and Neuronal Maturation

Authors
Levine A, Hukin J, Dunham C.

Journal
Pediatr Dev Pathol.

Advanced ADC Histogram, Perfusion, and Permeability Metrics Show an Association with Survival and Pseudoprogression in Newly Diagnosed Diffuse Intrinsic Pontine Glioma: A Report from the Pediatric Brain Tumor Consortium

Authors
Vajapeyam S, Brown D, Billups C, Patay Z, Vezina G, Shiroishi MS, Law M, Baxter P, Onar-Thomas A, Fangusaro JR, Dunkel IJ, Poussaint TY

Journal
American Journal of Neuroradiology

Differential kinase activity of ACVR1 G328V and R206H mutations with implications to possible TβRI cross-talk in diffuse intrinsic pontine glioma

Authors
Cao H, Jin M, Gao M, Zhou H, Tao YJ, Skolnick J.

Journal
Sci Rep.

Super Elongation Complex as a Targetable Dependency in Diffuse Midline Glioma

Authors
Dahl NA, Danis E, Balakrishnan I, Wang D, Pierce A, Walker FM, Gilani A, Serkova NJ, Madhavan K, Fosmire S, Green AL, Foreman NK, Venkataraman S, Vibhakar R

Journal
Cell Reports

PRIMAGE project: predictive in silico multiscale analytics to support childhood cancer personalised evaluation empowered by imaging biomarkers

Authors
Martí-Bonmatí L, Alberich-Bayarri Á, Ladenstein R, Blanquer I, Segrelles JD, Cerdá-Alberich L, Gkontra P, Hero B, García-Aznar JM, Keim D, Jentner W, Seymour K, Jiménez-Pastor A, González-Valverde I, Martínez de Las Heras B, Essiaf S, Walker D, Rochette M, Bubak M, Mestres J, Viceconti M, Martí-Besa G, Cañete A, Richmond P, Wertheim KY, Gubala T, Kasztelnik M, Meizner J, Nowakowski P, Gilpérez S, Suárez A, Aznar M, Restante G, Neri E.

Journal
Eur Radiol Exp.

Retrospective analysis on the consistency of MRI features with histological and molecular markers in diffuse intrinsic pontine glioma (DIPG)

Authors
Giagnacovo M, Antonelli M, Biassoni V, Schiavello E, Warmuth-Metz M, Buttarelli FR, Modena P, Massimino M

Journal
Child's Nervous System

A phase I study of sirolimus in combination with metronomic therapy (CHOAnome) in children with recurrent or refractory solid and brain tumors

Authors
Qayed M, Cash T, Tighiouart M, MacDonald TJ, Goldsmith KC, Tanos R, Kean L, Watkins B, Suessmuth Y, Wetmore C, Katzenstein HM

Journal
Pediatric Blood and Cancer

Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib

Authors
Wang Z, Xu C, Diplas BH, Moure CJ, Chen CJ, Chen LH, Du C, Zhu H, Greer PK, Zhang L, He Y, Waitkus MS, Yan H

Journal
Molecular Cancer Research

Retrospective analysis of the clinical and radiological features of 94 consecutive DIPGs patients to investigate the factors determining the development of hydrocephalus and its impact on clinical status and survival

Authors
Giussani C, Guida L, Biassoni V, Schiavello E, Carrabba G, Trezza A, Sganzerla E, Massimino M

Journal
Child’s Nervous System, 2020 Mar 28 [Epub ahead of print]

Diffuse intrinsic pontine glioma-like tumor with EZHIP expression and molecular features of PFA ependymoma

Authors
Pratt D, Quezado M, Abdullaev Z, Hawes D, Yang F, Garton HJL, Judkins AR, Mody R, Chinnaiyan A, Aldape K, Koschmann C, Venneti S

Journal
Acta Neuropathologica Communications

Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation

Authors
Castel D, Kergrohen T, Tauziède-Espariat A, Mackay A, Ghermaoui S, Lechapt E, Pfister SM, Kramm CM, Boddaert N, Blauwblomme T, Puget S, Beccaria K, Jones C, Jones DTW, Varlet P, Grill J, Debily MA

Journal
Acta Neuropathologica

Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas

Authors
Fortin J, Tian R, Zarrabi I, Hill G, Williams E, Sanchez-Duffhues G, Thorikay M, Ramachandran P, Siddaway R, Wong JF, Wu A, Apuzzo LN, Haight J, You-Ten A, Snow BE, Wakeham A, Goldhamer DJ, Schramek D, Bullock AN, Dijke PT, Hawkins C, Mak TW

Journal
Cancer Cell

Defining Optimal Target Volumes of Conformal Radiation Therapy for Diffuse Intrinsic Pontine Glioma

Authors
Tinkle CL, Simone B, Chiang J, Li X, Campbell K, Han Y, Li Y, Hover LD, Molitoris JK, Becksfort J, Lucas JT Jr, Patay Z, Baker SJ, Broniscer A, Merchant TE

Journal
International Journal of Radiation Oncology Biology Physics

Predicting Outcome In Childhood Diffuse Midline Gliomas Using Magnetic Resonance Imaging Based Texture Analysis

Authors
Szychot E, Youssef A, Ganeshan B, Endozo R, Hyare H, Gains J, Mankad K, Shankar A

Journal
Journal of Neuroradiology

Pharmacologic inhibition of lysine specific demethylase-1 (LSD1) as a therapeutic and immune-sensitization strategy in pediatric high grade glioma (pHGG)

Authors
Bailey CP, Figueroa M, Gangadharan A, Yang Y, Romero MM, Kennis BA, Yadavilli S, Henry V, Collier T, Monje M, Lee DA, Wang L, Nazarian J, Gopalakrishnan V, Zaky W, Becher OJ, Chandra J

Journal
Neuro-Oncology

Radiation dose response of neurologic symptoms during conformal radiotherapy for diffuse intrinsic pontine glioma

Authors
Tinkle CL, Campbell K, Han Y, Li Y, Bianski B, Broniscer A, Khan RB, Merchant TE

Journal
Journal of Neuro-Oncology, 2020 Mar;147(1):195-203

Generation of diffuse intrinsic pontine glioma mouse models by brainstem-targeted in utero electroporation

Authors
Patel SK, Hartley RM, Wei X, Furnish R, Escobar-Riquelme F, Bear H, Choi K, Fuller C, Phoenix TN

Journal
Neuro-Oncology

Indolent course of brainstem tumors with K27M-H3.3 mutation

Authors
Baroni LV, Solano-Paez P, Nobre L, Michaeli O, Hawkins C, Laughlin S, Bartels U, Ramaswamy V, Bouffet E

Journal
Pediatric Blood and Cancer

Sequential Targeting in Crosslinking Nanotheranostics for Tackling the Multibarriers of Brain Tumors

Authors
Wu H, Lu H, Xiao W, Yang J, Du H, Shen Y, Qu H, Jia B, Manna SK, Ramachandran M, Xue X, Ma Z, Xu X, Wang Z, He Y, Lam KS, Zawadzki RJ, Li Y, Lin TY

Journal
Advanced Materials

MRI Patterns of Extrapontine Lesion Extension in Diffuse Intrinsic Pontine Gliomas

Authors
Makepeace L, Scoggins M, Mitrea B, Li Y, Edwards A, Tinkle CL, Hwang S, Gajjar A, Patay Z

Journal
American Journal of Neuroradiology

Invaders Exposed: Understanding and Targeting Tumor Cell Invasion in Diffuse Intrinsic Pontine Glioma

Authors
Kluiver TA, Alieva M, van Vuurden DG, Wehrens EJ, Rios AC

Journal
Frontiers in Oncology

High-grade gliomas in adolescents and young adults highlight histomolecular differences with their adult and paediatric counterparts

Journal
Neuro-Oncology

Biopsy in diffuse pontine gliomas: expert neurosurgeon opinion-a survey from the SIOPE brain tumor group

Authors
Tejada S, Aquilina K, Goodden J, Pettorini B, Mallucci C, van Veelen ML, Thomale UW

Journal
Child's Nervous System

Modeling DIPG in the mouse brainstem

Authors
Siddaway R, Hawkins C

Journal
Neuro-Oncology

A Phase I/II Study of Veliparib (ABT-888) with Radiation and Temozolomide in Newly Diagnosed Diffuse Pontine Glioma: A Pediatric Brain Tumor Consortium Study.

Authors
Baxter PA, Su JM, Onar-Thomas A, Billups CA, Li XN, Poussaint TY, Smith ER, Thompson PA, Adekunsle A, Ansell P, Giranda VL, Paulino AC, Kilburn L, Quaddoumi I, Broniscer A, Blaney SM, Dunkel IJ, Fouladi M

Journal
Neuro-Oncology

Longitudinal Monitoring of Gd-DTPA Following Convection Enhanced Delivery in the Brainstem

Authors
Tosi U, Souweidane MM

Journal
World Neurosurgery

High Prevalence of Developmental Venous Anomaly in Diffuse Intrinsic Pontine Gliomas: A Pediatric Control Study

Authors
Roux A, Boddaert N, Grill J, Castel D, Zanello M, Zah-Bi G, Chrétien F, Lefevre E, Ros VD, Zerah M, Puget S, Pallud J, Varlet P

Journal
Neurosurgery

Diffuse intrinsic pontine gliomas: Diagnostic approach and treatment strategies

Authors
Janjua MB, Ban VS, El Ahmadieh TY, Hwang SW, Samdani AF, Price AV, Weprin BE, Batjer H

Journal
Journal of Clinical Neuroscience

Epigenetic reprogramming and chromatin accessibility in pediatric diffuse intrinsic pontine gliomas: a neural developmental disease

Authors
Mendez FM, Núñez FJ, Garcia-Fabiani MB, Haase S, Carney S, Gauss JC, Becher OJ, Lowenstein PR, Castro MG

Journal
Neuro-Oncology

H3K36me3, message from chromatin to DNA damage repair

Authors
Sun Z, Zhang Y, Jia J, FangSun Z, Zhang Y, Jia J, Fang Y, Tang Y, Wu H, Fang D Y, Tang Y, Wu H, Fang D

Journal
Cell & Bioscience

A New Treatment Opportunity for DIPG and Diffuse Midline Gliomas: 5-ALA Augmented Irradiation, the 5aai Regimen

Authors
Kast RE, Michael AP, Sardi I, Burns TC, Heiland T, Karpel-Massler G, Kamar FG, Halatsch ME

Journal
Brain Sciences

Combined Targeting of Mutant p53 and Jumonji Family Histone Demethylase Augments Therapeutic Efficacy of Radiation in H3K27M DIPG

Authors
Nikolaev A, Fiveash JB, Yang ES

Journal
International Journal of Molecular Sciences

Hypofractionated radiotherapy with temozolomide in diffuse intrinsic pontine gliomas: a randomized controlled trial

Authors
Izzuddeen Y, Gupta S, Haresh KP, Sharma D, Giridhar P, Rath GK

Journal
Journal of Neuro-Oncology

An atypical presentation of diffuse midline pontine glioma in a middle age patient: Case report

Authors
Floro S, Belvedere D, Rosci C, Secchi M, Casellato C, Oggioni G, Gambini C, Campiglio L, Zardoni M, Altavilla R, Bianchi F, D'Arrigo A, Bartesaghi F, Egidi M, Uggetti C, Giaccone G, Marucci G, Mastronuzzi A, Vinci M, Priori A

Journal
Journal of Clinical Neuroscience