Current Research Projects

Ongoing Research Projects:

• Establishment of Intra-brain Stem Xenograft Mouse Models and Permanent Cell Cultures of DIPG
• Patterns of cerebrospinal fluid diversion and survival in children with diffuse intrinsic pontine glioma
• Determining predictive factors of survival through clinicopathologic, genomic and radiographic analysis of infants < 3 years of age with Diffuse Intrinsic Pontine Glioma: A study from the International DIPG Registry
• Diffuse Intrinsic Pontine Glioma (DIPG): the Australian Experience
• Clinical, Radiological, Histological, and Molecular Characteristics of Patients with DIPG who Survive ≤ 3 months from Diagnosis Despite Therapy
• Re-irradiation of children with DIPG: practices and outcomes
• Characterizing temporal genomic heterogeneity in pediatric DIPG
• Elucidating lipid metabolic reprogramming in Diffuse Intrinsic Pontine Glioma
• Novel target discovery in Diffuse Midline Glioma
• Outcomes for children with spinal diffuse midline gliomas (sDMG): a DIPG Registry Study
• Defining Volumetric Endpoints for Tumor Response in Diffuse Intrinsic Pontine Glioma
• Clinical, Radiological, Histological, and Molecular Characteristics of Patients with Midline Gliomas in Canada
• Timing of Radiation Therapy Initiation and Association with Neurological Recovery in Patients with New Diagnosis of DIPG
• Retrospective assessment of the RAPNO DIPG criteria on a sample of patients from the DIPG Registry
• Improve Care Now: Assessing Health-Related Quality of Life in Patients Enrolled in the International DIPG Registry
• Non-DIPG Patients Enrolled in the International DIPG Registry: Histopathologic Evaluation of Central Neuro-Imaging Review
• Evaluation of the distribution and correlates of post-radiation and best responses over time in patients with diffuse intrinsic pontine glioma (DIPG): A IDIPGR Study

Completed Research Projects:

• Comprehensive Molecular-Based Cross-Species Comparison of DIPG Biology
• Radiogenomic Evaluation of Radiation Resistance in Diffuse Intrinsic Pontine Glioma
• A safety run-in, phase 2 trial of Convection Enhanced Delivery (CED) of Carboplatin and Sodium Valproate into the pons for the treatment of Diffuse Intrinsic Pontine Glioma (DIPG) after radiotherapy in children aged 3-17 years
• STAT3 expression in patients with diffused intrinsic pontine glioma

Manuscripts Published:

• Characteristics of Patients ≥ 10 Years of Age with Diffuse Intrinsic Pontine Glioma: A Report from the International DIPG Registry
• MR Imaging Features of Diffuse Intrinsic Pontine Glioma (DIPG) and Relationship to Overall Survival: Report From the International DIPG Registry
• Medulloblastoma therapy generates risk of a poorly-prognostic H3 wild-type subgroup of diffuse intrinsic pontine glioma: a report from the International DIPG Registry
• The International Diffuse Intrinsic Pontine Glioma Registry: an infrastructure to accelerate collaborative research for an orphan disease
• Development of the SIOPE DIPG Network, Registry and Imaging Repository: A collaborative effort to optimize research into a rare and lethal disease
• Contemporary Survival Endpoints: An International Diffuse Intrinsic Pontine Glioma Registry Study
• External validation of the diffuse intrinsic pontine glioma survival prediction model: a collaborative report from the International DIPG Registry and the SIOPE DIPG Registry
• Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries

To submit a research proposal please contact the Registry office.

Or access the application here.